Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles.
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ABSTRACT: Photoswitchable drugs are small-molecule optical probes that undergo chromatically selective control of drug efficacy using, most often, UV-visible light. Here we report that luminescence produced by near-infrared stimulation of NaYF4:TmYb nanoparticles can be used for "remote control" of an azobenzene-based photochromic ion channel blocker of neurons in living brain slices.
SUBMITTER: Zhao J
PROVIDER: S-EPMC7812838 | biostudies-literature |
REPOSITORIES: biostudies-literature
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