Dataset Information

Atherogenic dyslipidaemia and cardiovascular events in patients with diabetes or pre-diabetes and stable coronary artery disease: a prospective, cohort study.

ABSTRACT:

Objective

The aim of the study was to investigate the impacts of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) dyslipidaemia on prognosis in coronary artery disease (CAD) patients with different glucose metabolism status.

Design

An observational cohort study.

Setting/participants

A total of 3057 patients with stable CAD were consecutively enrolled and divided into three groups according to different glucose metabolism status. Atherogenic dyslipidaemia (AD) was defined as TG ?1.7 mmol/L and HDL-C <1.0 mmol/L for men or <1.3 mmol/L for women. The patients were further classified into six subgroups by status of AD. All subjects were followed up for the cardiovascular events (CVEs).

Primary outcome measures

The primary endpoints were cardiovascular mortality, non-fatal myocardial infarction and non-fatal stroke.

Results

During a median follow-up of 6.1 years, 308 (10.1%) CVEs occurred. No significant difference in the occurrence of CVEs was observed between normal glucose regulation (NGR) and pre-diabetes (pre-DM) groups (HR: 1.25, 95% CI 0.89 to 1.76) while DM group presented 1.45-fold higher risk of CVEs (HR: 1.45, 95% CI 1.02 to 2.05). When the participants were categorised according to combined status of two parameters, the cardiovascular risk was significantly elevated in pre-DM or DM plus AD group compared with the NGR plus non-AD group (HR: 1.76, 95% CI 1.10 to 2.80 and HR: 1.87, 95% CI 1.17 to 2.98).

Conclusions

The present study suggested that the presence of AD might affect the prognosis in patients with DM or pre-DM and stable CAD.

SUBMITTER: Jin JL

PROVIDER: S-EPMC7813370 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Atherogenic dyslipidaemia and cardiovascular events in patients with diabetes or pre-diabetes and stable coronary artery disease: a prospective, cohort study.

Jin Jing-Lu JL Cao Ye-Xuan YX Wu Li-Guo LG You Xiang-Dong XD Guo Na N Guo Yuan-Lin YL Wu Na-Qiong NQ Zhu Cheng-Gang CG Xu Rui-Xia RX Liu Hui-Hui HH Sun Jing J Dong Qian Q Gao Ying Y Li Jian-Jun JJ

BMJ open 20210117 1

<h4>Objective</h4>The aim of the study was to investigate the impacts of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) dyslipidaemia on prognosis in coronary artery disease (CAD) patients with different glucose metabolism status.<h4>Design</h4>An observational cohort study.<h4>Setting/participants</h4>A total of 3057 patients with stable CAD were consecutively enrolled and divided into three groups according to different glucose metabolism status. Atherogenic dyslipidaemia ( ...[more]

PMID: 33455923

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Dataset Information

Atherogenic dyslipidaemia and cardiovascular events in patients with diabetes or pre-diabetes and stable coronary artery disease: a prospective, cohort study.

Objective

Design

Setting/participants

Primary outcome measures

Results

Conclusions

Publications

Atherogenic dyslipidaemia and cardiovascular events in patients with diabetes or pre-diabetes and stable coronary artery disease: a prospective, cohort study.

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