Ontology highlight
ABSTRACT:
SUBMITTER: Garg S
PROVIDER: S-EPMC7813477 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Garg Surbhi S Sagar Amin A Singaraju Gayathri S GS Dani Rahul R Bari Naimat K NK Naganathan Athi N AN Rakshit Sabyasachi S
The Biochemical journal 20210101 1
Age-related hearing loss (ARHL) is a common condition in humans marking the gradual decrease in hearing with age. Perturbations in the tip-link protein cadherin-23 that absorbs the mechanical tension from sound and maintains the integrity of hearing is associated with ARHL. Here, in search of molecular origins for ARHL, we dissect the conformational behavior of cadherin-23 along with the mutant S47P that progresses the hearing loss drastically. Using an array of experimental and computational ap ...[more]