GATA3 somatic mutations are associated with clinicopathological features and expression profile in TCGA breast cancer patients.

ABSTRACT: The effect of somatic mutations and the gene expression profiles on the prognosis is well documented in cancer research. This study was conducted to evaluate the association of GATA3 somatic mutations with tumor features, survival, and expression profiles in breast cancer. Clinicopathological information was compared between TCGA-BRCA patients with GATA3-mutant and non-mutant tumors in all patients as well as in ER-positive subgroup. Cox-regression method was used to evaluate the association of the GATA3 mutation status with overall survival time. Differential gene expression, functional annotation, and protein-protein interaction analyses were performed using edgeR, Metascape, DAVID, STRING and CytoNCA. GATA3-mutant and non-mutant samples had significantly different clinicopathological features (p?adj?=?0.52), the GATA3-wild type ER-positive cases had a better prognosis than mutant ones (p_adj?=?0.04). GATA3 expression was higher in tumors than normal tissues. Several pathways were different between mutant and non-mutant groups (p?

SUBMITTER: Afzaljavan F 

PROVIDER: S-EPMC7814117 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature