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Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane.

ABSTRACT: An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst, highly toxic or corrosive reagents. Notably, we demonstrate the potential utility of halothane for the synthesis of aryl gem-difluoroalkyl ethers containing the bromochloromethyl group.

SUBMITTER: Karuo Y

PROVIDER: S-EPMC7814179 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane.

Karuo Yukiko Y Kametani Ayaka A Tarui Atsushi A Sato Kazuyuki K Kawai Kentaro K Omote Masaaki M

Beilstein journal of organic chemistry 20210111

An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst, highly toxic or corrosive reagents. Notably, we demonstrate the potential utility of halothane for the synthesis of aryl <i>gem</i>-difluoroalkyl ethers containing the bromochloromethyl group. ...[more]

PMID: 33519995

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