Unknown

Dataset Information

0

Age-Specific Acute Changes in Carotid-Femoral Pulse Wave Velocity With Head-up Tilt.


ABSTRACT:

Background

Aortic stiffness as measured by carotid-femoral pulse wave velocity (cfPWV) is known to depend on blood pressure (BP), and this dependency may change with age. Therefore, the hydrostatic BP gradient resulting from a change in body posture may elicit a cfPWV change that is age-dependent. We aimed to analyze the relationship between BP gradient-induced by head-up body tilting-and related changes in cfPWV in individuals of varying age.

Methods

cfPWV and other hemodynamic parameters were measured in 30 healthy individuals at a head-up tilt of 0° (supine), 30°, and 60°. At each angle, the PWV gradient and resulting cfPWV were also estimated (predicted) by assuming a global nonlinear, exponential, pressure-diameter relationship characterized by a constant ?0, and taking into account that (diastolic) foot-to-foot cfPWV acutely depends on diastolic BP.

Results

cfPWV significantly increased upon body tilting (8.0 ± 2.0 m/s supine, 9.1 ± 2.6 m/s at 30°, 9.5 ± 3.2 m/s at 60°, P for trend <0.01); a positive trend was also observed for heart rate (HR; P < 0.01). When the observed, tilt-induced cfPWV change measured by applanation tonometry was compared with that predicted from the estimated BP hydrostatic gradient, the difference in observed-vs.-predicted PWV change increased nonlinearly as a function of age (R2 for quadratic trend = 0.38, P < 0.01, P vs. linear = 0.04). This result was unaffected by HR tilt-related variations (R2 for quadratic trend = 0.37, P < 0.01, P vs. linear = 0.04).

Conclusions

Under a hydrostatic pressure gradient, the pulse wave traveling along the aorta undergoes an age-related, nonlinear PWV increase exceeding the increase predicted from BP dependency.

SUBMITTER: Pucci G 

PROVIDER: S-EPMC7814224 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Age-Specific Acute Changes in Carotid-Femoral Pulse Wave Velocity With Head-up Tilt.

Pucci Giacomo G   Spronck Bart B   Avolio Alberto P AP   Tap Lisanne L   Vaudo Gaetano G   Anastasio Fabio F   Van Den Meiracker Anton A   Mattace-Raso Francesco F  

American journal of hypertension 20201201 12


<h4>Background</h4>Aortic stiffness as measured by carotid-femoral pulse wave velocity (cfPWV) is known to depend on blood pressure (BP), and this dependency may change with age. Therefore, the hydrostatic BP gradient resulting from a change in body posture may elicit a cfPWV change that is age-dependent. We aimed to analyze the relationship between BP gradient-induced by head-up body tilting-and related changes in cfPWV in individuals of varying age.<h4>Methods</h4>cfPWV and other hemodynamic p  ...[more]

Similar Datasets

| S-EPMC7854542 | biostudies-literature
| S-EPMC4055813 | biostudies-other
| S-EPMC8989757 | biostudies-literature
| S-EPMC4818522 | biostudies-literature
| S-EPMC7415670 | biostudies-literature
| S-EPMC3579355 | biostudies-literature
| S-EPMC10488425 | biostudies-literature
| S-EPMC9731589 | biostudies-literature
| S-EPMC5377988 | biostudies-literature
| S-EPMC7792427 | biostudies-literature