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ABSTRACT: Background
Lymph node ratio (LNR) has been suggested to be an effective prognostic tool for stratifying non-small cell lung cancer (NSCLC) cases. In this study, we sought to determine cancer-specific survival (CCS) of NSCLC cases from the SEER registry and used the X-tile method to optimize CCS-based LNR cut-off points for prognostic stratification of node-positive NSCLC.Methods
CSS and other clinicopathologic variables were retrieved from the SEER registry. Kaplan-Meier methods were used to calculate CSS. The optimal cut-off points for LNR classification were determined by the X-tile approach. Multivariate Cox regression analysis was performed to identify independent risks of CSS.Results
Totally 11,341 lung cancer patients were included. Their median CSS was 22?months (range 0,143). The median LNR was 0.22 (Q1,Q3: 0.11, 0.50). X-tile analysis showed that the optimal LNR cut-off points were 0.28 and 0.81, dividing the cohort into low (LNR1???0.28; n?=?6580, 58%), middle (0.28??0.81; n?=?1736, 15.3%) subsets. Kaplan-Meier analysis showed that patients with a low LNR had a significantly higher CCS versus patients with middle or high LNR (P?ConclusionsLNR is an independent prognostic factor of node-positive NSCLC and its optimal cut-off values established using the robust x-tile method effectively define subpopulations of node-positive NSCLC cases, which is important in guiding selection of treatment strategies clinically.
SUBMITTER: Kai L
PROVIDER: S-EPMC7814600 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Kai Liu L Zhoumiao Chen C Shaohua Xu X Zhao Chen C Zhijun Li L Zhengfu He H Xiujun Cai C
Journal of cardiothoracic surgery 20210119 1
<h4>Background</h4>Lymph node ratio (LNR) has been suggested to be an effective prognostic tool for stratifying non-small cell lung cancer (NSCLC) cases. In this study, we sought to determine cancer-specific survival (CCS) of NSCLC cases from the SEER registry and used the X-tile method to optimize CCS-based LNR cut-off points for prognostic stratification of node-positive NSCLC.<h4>Methods</h4>CSS and other clinicopathologic variables were retrieved from the SEER registry. Kaplan-Meier methods ...[more]