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Patch-wise brain age longitudinal reliability.


ABSTRACT: We recently introduced a patch-wise technique to estimate brain age from anatomical T1-weighted magnetic resonance imaging (T1w MRI) data. Here, we sought to assess its longitudinal reliability by leveraging a unique dataset of 99 longitudinal MRI scans from a single, cognitively healthy volunteer acquired over a period of 17?years (aged 29-46?years) at multiple sites. We built a robust patch-wise brain age estimation framework on the basis of 100 cognitively healthy individuals from the MindBoggle dataset (aged 19-61?years) using the Desikan-Killiany-Tourville atlas, then applied the model to the volunteer dataset. The results show a high prediction accuracy on the independent test set (R2 = .94, mean absolute error of 0.63?years) and no statistically significant difference between manufacturers, suggesting that the patch-wise technique has high reliability and can be used for longitudinal multi-centric studies.

SUBMITTER: Beheshti I 

PROVIDER: S-EPMC7814761 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Patch-wise brain age longitudinal reliability.

Beheshti Iman I   Potvin Olivier O   Duchesne Simon S  

Human brain mapping 20201118 3


We recently introduced a patch-wise technique to estimate brain age from anatomical T1-weighted magnetic resonance imaging (T1w MRI) data. Here, we sought to assess its longitudinal reliability by leveraging a unique dataset of 99 longitudinal MRI scans from a single, cognitively healthy volunteer acquired over a period of 17 years (aged 29-46 years) at multiple sites. We built a robust patch-wise brain age estimation framework on the basis of 100 cognitively healthy individuals from the MindBog  ...[more]

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