Disease aggressiveness signatures of amyotrophic lateral sclerosis in white matter tracts revealed by the D50 disease progression model.
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ABSTRACT:
SUBMITTER: Steinbach R
PROVIDER: S-EPMC7814763 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Disease aggressiveness signatures of amyotrophic lateral sclerosis in white matter tracts revealed by the D50 disease progression model.
Steinbach Robert R Gaur Nayana N Roediger Annekathrin A Mayer Thomas E TE Witte Otto W OW Prell Tino T Grosskreutz Julian J
Human brain mapping 20201026 3
Numerous neuroimaging studies in amyotrophic lateral sclerosis (ALS) have reported links between structural changes and clinical data; however phenotypic and disease course heterogeneity have occluded robust associations. The present study used the novel D50 model, which distinguishes between disease accumulation and aggressiveness, to probe correlations with measures of diffusion tensor imaging (DTI). DTI scans of 145 ALS patients and 69 controls were analyzed using tract-based-spatial-statisti ...[more]
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