Ontology highlight
ABSTRACT:
SUBMITTER: Sarma A
PROVIDER: S-EPMC7814832 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Sarma Aartik A Christenson Stephanie A SA Mick Eran E DeVoe Catherine C Deiss Thomas T Pisco Angela Oliveira AO Ghale Rajani R Jauregui Alejandra A Byrne Ashley A Moazed Farzad F Spottiswoode Natasha N Sinha Pratik P Zha Beth Shoshana BS Neff Norma N Tan Michelle M Serpa Paula Hayakawa PH Ansel K Mark KM Wilson Jennifer G JG Leligdowicz Aleksandra A Siegel Emily R ER Sirota Marina M DeRisi Joseph L JL Matthay Michael A MA Hendrickson Carolyn M CM Kangelaris Kirsten N KN Krummel Matthew F MF Woodruff Prescott G PG Erle David J DJ Calfee Carolyn S CS Langelier Charles R CR
Research square 20210114
We performed comparative lower respiratory tract transcriptional profiling of 52 critically ill patients with the acute respiratory distress syndrome (ARDS) from COVID-19 or from other etiologies, as well as controls without ARDS. In contrast to a cytokine storm, we observed reduced proinflammatory gene expression in COVID-19 ARDS when compared to ARDS due to other causes. COVID-19 ARDS was characterized by a dysregulated host response with increased PTEN signaling and elevated expression of gen ...[more]