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Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors.

ABSTRACT: Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6%), thyroid (21.0%), ovary (10.5%), and breast (10.5%). Uterine fibroid was the most common benign tumor (37.6%) in women, while pilomatricoma was the most common in men (28.6%). Age at enrollment (OR = 1.02, 95% CI 1.00-1.05), and female gender (OR = 5.71, 95% CI 2.90-11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95% CI 1.35-19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.

SUBMITTER: Bianchi ML

PROVIDER: S-EPMC7814867 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors.

Bianchi Maria Laura Ester ML Leoncini Emanuele E Masciullo Marcella M Modoni Anna A Gadalla Shahinaz M SM Massa Roberto R Rastelli Emanuele E Terracciano Chiara C Antonini Giovanni G Bucci Elisabetta E Petrucci Antonio A Costanzi Sandro S Santoro Massimo M Boccia Stefania S Silvestri Gabriella G

Journal of neurology 20160106 3

Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tum ...[more]

PMID: 26739382

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Project description:Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence. We aimed to examine possible gender differences in cardiometabolic risk factors and lifestyle behaviors among adolescents with severe obesity, hypothesizing that boys would have both a higher prevalence of the metabolic syndrome as well as less healthy lifestyle behaviors than girls.Cross-sectional study of treatment-seeking adolescents with severe obesity who attended the Morbid Obesity Centre at Vestfold Hospital Trust and who were consecutively enrolled in the Vestfold Register of Obese Children between September 2009 and September 2015. A total of 313 adolescents aged 12 to 18 years were recruited, whereof 268 subjects (49% boys) completed a food and activity frequency questionnaire and were included in the analysis.Mean (SD) age, BMI and BMI SDS were 15 (1.6) years, 38.6 (5.9) kg/m2 and 3.5 (0.6). Levels of LDL cholesterol, fasting insulin and glucose and diastolic blood pressure (DBP) did not differ between genders. Compared to girls, boys had significantly higher triglycerides (p =?0.037) and systolic blood pressure (SBP) (p =?0.003), as well as lower HDL cholesterol (p =?0.002). The metabolic syndrome was present in 27% of the boys and 19% of the girls (p =?0.140), and the prevalence of high DBP, dyslipidemia and dysglycemia also did not differ significantly between genders. The prevalence of high SBP was higher in boys than in girls (19% vs. 9%, p =?0.021). Gender was associated with a number of lifestyle habits, as a larger proportions of boys had higher screen time (p =?0.032), more regular breakfast eating (p =?0.023), higher intake of sugar sweetened soda (p =?0.036), and lower intake of vegetables than girls (p =?0.011). By contrast, physical activity level and intake of fruit and berries did not differ between genders.Male treatment-seeking adolescents with severe obesity had a more unfavorable set of metabolic and behavioral risk factors for cardiovascular disease than girls. Our results indicate that lifestyle behavioral markers should be thoroughly assessed in both genders, and possible gender-related differences in risk profile should be taken into account in future treatment programs.

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Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors.

Publications

Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors.

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