Ontology highlight
ABSTRACT:
SUBMITTER: Light JG
PROVIDER: S-EPMC7815086 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Clinical, cosmetic and investigational dermatology 20210115
Psoriasis is a chronic immune-mediated disease involving complex interaction of T cells and keratinocytes. The comprehensive pathogenesis of psoriasis is not fully understood but the IL-23/Th17 axis is a central pathway in driving disease development. Guselkumab is the first treatment of moderate-to-severe psoriasis that specifically targets the p19 subunit of IL-23. The benefit of guselkumab has been established by a number of clinical trials including demonstration of greater long-term efficac ...[more]