Ontology highlight
ABSTRACT:
SUBMITTER: Vjestica A
PROVIDER: S-EPMC7815208 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Vještica Aleksandar A Bérard Melvin M Liu Gaowen G Merlini Laura L Nkosi Pedro Junior PJ Martin Sophie G SG
PLoS biology 20210106 1
To ensure genome stability, sexually reproducing organisms require that mating brings together exactly 2 haploid gametes and that meiosis occurs only in diploid zygotes. In the fission yeast Schizosaccharomyces pombe, fertilization triggers the Mei3-Pat1-Mei2 signaling cascade, which represses subsequent mating and initiates meiosis. Here, we establish a degron system to specifically degrade proteins postfusion and demonstrate that mating blocks not only safeguard zygote ploidy but also prevent ...[more]