Extended gate field-effect-transistor for sensing cortisol stress hormone.

ABSTRACT: Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect transistor (EG-FET) for the recognition of cortisol in biological buffers within the Debye screening length. The device shows promising experimental features for real-time monitoring of the circadian rhythm of cortisol in human sweat. We report a hysteresis-free EG-FET with a voltage sensitivity of the order of 14?mV/decade and current sensitivity up to 80% over the four decades of cortisol concentration. The detection limit is 0.2?nM over a wide range, between 1?nM and 10?µM, of cortisol concentrations in physiological fluid, with negligible drift over time and high selectivity. The dynamic range fully covers those in human sweat. We propose a comprehensive analysis and a unified, predictive analytical mapping of current sensitivity in all regimes of operation.

SUBMITTER: Sheibani S 

PROVIDER: S-EPMC7815575 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature