Ontology highlight
ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC7815645 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in cell and developmental biology 20210106
Formation of the <i>trans</i>-SNARE complex is believed to generate a force transfer to the membranes to promote membrane fusion, but the underlying mechanism remains elusive. In this study, we show that helix-breaking and/or length-increasing insertions in the juxtamembrane linker region of synaptobrevin-2 exert diverse effects on liposome fusion, in a manner dependent on the insertion position relative to the two conserved tryptophan residues (W<sup>89</sup>/W<sup>90</sup>). Helical extension ...[more]