Ontology highlight
ABSTRACT:
SUBMITTER: Kusy D
PROVIDER: S-EPMC7815931 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20210106
Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-<i>a</i>]pyridin-3-<i>yl</i>-2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature of the substituent in the C6 position of imidazo[1,2-<i>a</i>]pyridine ring was responsible for the compound's activity against Rab geranylgeranyl transferase (RGGT). The most active inhibitors disrupted Rab11A prenylation in the human cervical carcinoma HeLa ce ...[more]