Ontology highlight
ABSTRACT:
SUBMITTER: Chi Y
PROVIDER: S-EPMC7816199 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20200701 6501
The tumor microenvironment plays a critical regulatory role in cancer progression, especially in central nervous system metastases. Cancer cells within the cerebrospinal fluid (CSF)-filled leptomeninges face substantial microenvironmental challenges, including inflammation and sparse micronutrients. To investigate the mechanism by which cancer cells in these leptomeningeal metastases (LM) overcome these constraints, we subjected CSF from five patients with LM to single-cell RNA sequencing. We fo ...[more]