Ontology highlight
ABSTRACT: Aims
We aimed to create a tumor recurrent-based prediction model to predict recurrence and survival in patients with low-grade glioma.Methods
This study enrolled 291 patients (188 in the training group and 103 in the validation group) with clinicopathological information and transcriptome sequencing data. LASSO-COX algorithm was applied to shrink predictive factor size and build a predictive recurrent signature. GO, KEGG, and GSVA analyses were performed for function annotations of the recurrent signature. The calibration curves and C-Index were assessed to evaluate the nomogram's performance.Results
This study found that DNA repair functions of tumor cells were significantly enriched in recurrent low-grade gliomas. A predictive recurrent signature, built by the LASSO-COX algorithm, was significantly associated with overall survival and progression-free survival in low-grade gliomas. Moreover, function annotations analysis of the predictive recurrent signature exhibited that the signature was associated with DNA repair functions. The nomogram, combining the predictive recurrent signature and clinical prognostic predictors, showed powerful prognostic ability in the training and validation groups.Conclusion
An individualized prediction model was created to predict 1-, 2-, 3-, 5-, and 10-year survival and recurrent rate of patients with low-grade glioma, which may serve as a potential tool to guide postoperative individualized care.
SUBMITTER: Li G
PROVIDER: S-EPMC7816205 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
CNS neuroscience & therapeutics 20201016 2
<h4>Aims</h4>We aimed to create a tumor recurrent-based prediction model to predict recurrence and survival in patients with low-grade glioma.<h4>Methods</h4>This study enrolled 291 patients (188 in the training group and 103 in the validation group) with clinicopathological information and transcriptome sequencing data. LASSO-COX algorithm was applied to shrink predictive factor size and build a predictive recurrent signature. GO, KEGG, and GSVA analyses were performed for function annotations ...[more]