Focused ultrasound robotic system for very small bore magnetic resonance imaging.
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ABSTRACT: Background
A magnetic resonance imaging (MRI) compatible robotic system for focused ultrasound was developed for small animal like mice or rats that fits into a 9.4 T MRI scanner (Bruker Biospec 9420, Bruker Biospin, Ettlingen, Germany). The robotic system includes two computer-controlled linear stages.Materials and methods
The robotic system was evaluated in a mouse-shaped, real-size agar-based mimicking material, which has similar acoustical properties as soft tissues. The agar content was 6% weight per volume (w/v), 4% w/v silica while the rest was degassed water. The transducer used has a diameter of 4 cm, operates with 2.6 MHz and focuses energy at 5 cm.Results
The MRI compatibility of the robotic system was evaluated in a 9.4 T small animal scanner. The efficacy of the ultrasonic transducer was evaluated in the mimicking material using temperature measurements.Conclusions
The proposed robotic system can be utilized in a 9.4 T small animal MRI scanner. The proposed system is functional, compact and simple thus providing a useful tool for preclinical research in mice and rats.
SUBMITTER: Damianou C
PROVIDER: S-EPMC7816236 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Focused ultrasound robotic system for very small bore magnetic resonance imaging.
Damianou Christakis C Giannakou Marinos M Evripidou Nikolas N Kegel Stefan S Huber Peter P Jenne Juergen J
The international journal of medical robotics + computer assisted surgery : MRCAS 20200922 6
<h4>Background</h4>A magnetic resonance imaging (MRI) compatible robotic system for focused ultrasound was developed for small animal like mice or rats that fits into a 9.4 T MRI scanner (Bruker Biospec 9420, Bruker Biospin, Ettlingen, Germany). The robotic system includes two computer-controlled linear stages.<h4>Materials and methods</h4>The robotic system was evaluated in a mouse-shaped, real-size agar-based mimicking material, which has similar acoustical properties as soft tissues. The agar ...[more]
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