Prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC).

ABSTRACT: This study attempts to evaluate the prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC) by means of publicly available data from The Cancer Genome Atlas (TCGA). Clinical pathologic features and PHYH expression were downloaded from the TCGA database and relationships between them were analyzed by univariate and multivariate Cox regression analyses. Gene Set Enrichment Analysis (GSEA) and gene-gene interactions were also performed between tissues with different PHYH expression levels. PHYH expression levels were significantly lower in patient with ccRCC compared with normal tissues (p = 1.156e-19). Kaplan-Meier survival analysis showed that high expression of PHYH had a better prognosis than low expression (p = 9e-05). Moreover, PHYH expression was al

SUBMITTER: Zhengqi Q 

PROVIDER: S-EPMC7816304 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature