Dataset Information

Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study.

ABSTRACT:

Background

Interstitial lung abnormalities (ILA) can be detected on computed tomography (CT) in lung cancer patients and have an association with mortality in advanced non-small cell lung cancer (NSCLC) patients. The aim of this study is to demonstrate the significance of ILA for mortality in patients with stage I NSCLC using Boston Lung Cancer Study cohort.

Methods

Two hundred and thirty-one patients with stage I NSCLC from 2000 to 2011 were investigated in this retrospective study (median age, 69?years; 93 males, 138 females). ILA was scored on baseline CT scans prior to treatment using a 3-point scale (0?=?no evidence of ILA, 1?=?equivocal for ILA, 2?=?ILA) by a sequential reading method. ILA score 2 was considered the presence of ILA. The difference of overall survival (OS) for patients with different ILA scores were tested via log-rank test and multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) including ILA score, age, sex, smoking status, and treatment as the confounding variables.

Results

ILA was present in 22 out of 231 patients (9.5%) with stage I NSCLC. The presence of ILA was associated with shorter OS (patients with ILA score 2, median 3.85?years [95% confidence interval (CI): 3.36 - not reached (NR)]; patients with ILA score 0 or 1, median 10.16?years [95%CI: 8.65 - NR]; P?ConclusionsILA was detected on CT in 9.5% of patients with stage I NSCLC. The presence of ILA was significantly associated with a shorter OS and could be an imaging marker of shorter survival in stage I NSCLC.

SUBMITTER: Hida T

PROVIDER: S-EPMC7816399 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study.

Hida Tomoyuki T Hata Akinori A Lu Junwei J Valtchinov Vladimir I VI Hino Takuya T Nishino Mizuki M Honda Hiroshi H Tomiyama Noriyuki N Christiani David C DC Hatabu Hiroto H

Cancer imaging : the official publication of the International Cancer Imaging Society 20210119 1

<h4>Background</h4>Interstitial lung abnormalities (ILA) can be detected on computed tomography (CT) in lung cancer patients and have an association with mortality in advanced non-small cell lung cancer (NSCLC) patients. The aim of this study is to demonstrate the significance of ILA for mortality in patients with stage I NSCLC using Boston Lung Cancer Study cohort.<h4>Methods</h4>Two hundred and thirty-one patients with stage I NSCLC from 2000 to 2011 were investigated in this retrospective stu ...[more]

PMID: 33468255

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Dataset Information

Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study.

Background

Methods

Results

Publications

Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study.

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