Ontology highlight
ABSTRACT:
SUBMITTER: Voigts J
PROVIDER: S-EPMC7817180 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Voigts Jakob J Deister Christopher A CA Moore Christopher I CI
eLife 20201202
Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory neocortex. We found that deviant stimuli enhanced tactile detection and were encoded in L2/3 neural tuning. To test the contribution of L6, we applied weak optogenetic drive that changed which L6 neurons were sensory responsive, without affectin ...[more]