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X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom.


ABSTRACT: Minibeam radiation therapy (MBRT) is a type of spatial fractionated radiotherapy that uses submillimetric beams. This work reports on a pilot study on normal tissue response and the increase of the lifespan of glioma-bearing rats when irradiated with a tabletop x-ray system. Our results show a significant widening of the therapeutic window for brain tumours treated with MBRT: an important proportion of long-term survivals (60%) coupled with a significant reduction of toxicity when compared with conventional (broad beam) irradiations. In addition, the clinical translation of the minibeam treatment at a conventional irradiator is evaluated through a possible human head treatment plan.

SUBMITTER: Sotiropoulos M 

PROVIDER: S-EPMC7817429 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom.

Sotiropoulos Marios M   Brisebard Elise E   Le Dudal Marine M   Jouvion Gregory G   Juchaux Marjorie M   Crépin Delphine D   Sebrie Catherine C   Jourdain Laurene L   Labiod Dalila D   Lamirault Charlotte C   Pouzoulet Frederic F   Prezado Yolanda Y  

Clinical and translational radiation oncology 20210108


Minibeam radiation therapy (MBRT) is a type of spatial fractionated radiotherapy that uses submillimetric beams. This work reports on a pilot study on normal tissue response and the increase of the lifespan of glioma-bearing rats when irradiated with a tabletop x-ray system. Our results show a significant widening of the therapeutic window for brain tumours treated with MBRT: an important proportion of long-term survivals (60%) coupled with a significant reduction of toxicity when compared with  ...[more]

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