Ontology highlight
ABSTRACT:
SUBMITTER: Tangella LP
PROVIDER: S-EPMC7817430 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Computational and structural biotechnology journal 20201230
The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little is known about its structure and drug-binding sites. In this study, we generated an atomistic model of the full-length human ABCB5 transporter with the highest quality using the X-ray crystal structure of mouse ABCB1 (Pgp1), a close homologue of ABCB5 and a well-studied member of the ABC family. Molecular dynamics simu ...[more]