Mitochondrial DNA analysis efficiently contributes to the identification of metastatic contralateral breast cancers.

ABSTRACT:

Purpose

In daily practice, a contralateral breast cancer (CBC) is usually considered as a new independent tumor despite the indications of several studies showing that the second neoplasia may be a metastatic spread of the primary tumor. Recognition of clonal masses in the context of multiple synchronous or metachronous tumors is crucial for correct prognosis, therapeutic choice, and patient management. Mitochondrial DNA (mtDNA) sequencing shows high informative potential in the diagnosis of synchronous neoplasms, based on the fact that somatic mtDNA mutations are non-recurrent events, whereas tumors sharing them have a common origin. We here applied this technique to reveal clonality of the CBC with respect to the first tumor.

Methods

We analyzed 30 sample pairs of primary

SUBMITTER: Girolimetti G 

PROVIDER: S-EPMC7817585 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature