BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.
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ABSTRACT:
SUBMITTER: Choi GE
PROVIDER: S-EPMC7817668 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.
Choi Gee Euhn GE Lee Hyun Jik HJ Chae Chang Woo CW Cho Ji Hyeon JH Jung Young Hyun YH Kim Jun Sung JS Kim Seo Yihl SY Lim Jae Ryong JR Han Ho Jae HJ
Nature communications 20210120 1
Stress-induced glucocorticoids disturb mitochondrial bioenergetics and dynamics; however, instead of being removed via mitophagy, the damaged mitochondria accumulate. Therefore, we investigate the role of glucocorticoids in mitophagy inhibition and subsequent synaptic defects in hippocampal neurons, SH-SY5Y cells, and ICR mice. First, we observe that glucocorticoids decrease both synaptic density and vesicle recycling due to suppressed mitophagy. Screening data reveal that glucocorticoids downre ...[more]
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