Ontology highlight
ABSTRACT:
SUBMITTER: Mody V
PROVIDER: S-EPMC7817688 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Mody Vicky V Ho Joanna J Wills Savannah S Mawri Ahmed A Lawson Latasha L Ebert Maximilian C C J C MCCJC Fortin Guillaume M GM Rayalam Srujana S Taval Shashidharamurthy S
Communications biology 20210120 1
Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to public health. The morbidity is increasing due to lack of SARS-CoV-2 specific drugs. Herein, we have identified potential drugs that target the 3-chymotrypsin like protease (3CLpro), the main protease that is pivotal for the replication of SARS-CoV-2. Computational molecular modeling was used to screen 3987 FDA approved drugs, and 47 drugs were selected to study their inhibitory effec ...[more]