Short H2A histone variants are expressed in cancer.
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ABSTRACT:
SUBMITTER: Chew GL
PROVIDER: S-EPMC7817690 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Short H2A histone variants are expressed in cancer.
Chew Guo-Liang GL Bleakley Marie M Bradley Robert K RK Malik Harmit S HS Henikoff Steven S Molaro Antoine A Sarthy Jay J
Nature communications 20210120 1
Short H2A (sH2A) histone variants are primarily expressed in the testes of placental mammals. Their incorporation into chromatin is associated with nucleosome destabilization and modulation of alternate splicing. Here, we show that sH2As innately possess features similar to recurrent oncohistone mutations associated with nucleosome instability. Through analyses of existing cancer genomics datasets, we find aberrant sH2A upregulation in a broad array of cancers, which manifest splicing patterns c ...[more]
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