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Antidiabetic effects of Maclura cochinchinensis (Lour.) corner heartwood extract.

ABSTRACT:

Background and aim

Maclura cochinchinensis (MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated.

Experimental procedure

This study investigated the effects of an aqueous heartwood extract of MC on ?-glucosidase and ?-amylase activities. Moreover, its antidiabetic effect was evaluated using an oral glucose tolerance test (OGTT) and a 28-day administration to streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic mice.

Results

In both OGTT and the daily oral administration for 28 days in STZ-NA-induced type 2 diabetic mice models, the extract (1,000?mg/kg) significantly decreased fasting blood glucose. This hypoglycemic effect was explained by increased insulin levels and ?-glucosidase inhibition (IC₅₀:1.53?±?0.03??g/mL).

Conclusion

This first study on the hypoglycemic activity of MC heartwood extract indicates that it could be a potential natural remedy for type 2 diabetes.

SUBMITTER: Chewchinda S

PROVIDER: S-EPMC7817708 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Antidiabetic effects of <i>Maclura cochinchinensis</i> (Lour.) corner heartwood extract.

Chewchinda Savita S Leakaya Nantakarn N Sato Hitoshi H Sato Vilasinee Hirunpanich VH

Journal of traditional and complementary medicine 20191022 1

<h4>Background and aim</h4><i>Maclura cochinchinensis</i> (MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated.<h4>Experimental procedure</h4>This study investigated the effects of an aqueous heartwood extract of MC on α-glucosidase and α-amylase activities. Moreover, its antidiabetic effect was evaluated using an oral glucose tolerance test (OGTT) and a 28-day administration to streptozotocin (STZ)-nicot ...[more]

PMID: 33511064

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