Ontology highlight
ABSTRACT:
SUBMITTER: Hansson O
PROVIDER: S-EPMC7818141 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Annals of clinical and translational neurology 20201129 1
We examined if plasma phosphorylated tau is associated with neurodegeneration in Alzheimer's disease. We investigated 372 cognitively unimpaired participants, 554 mild cognitive impairment patients, and 141 Alzheimer's disease dementia patients. Tau phosphorylated at threonine 181, regional cortical thickness (using magnetic resonance imaging) and hypometabolism (using fluorodeoxyglucose positron emission tomography) were measured longitudinally. High plasma tau was associated with hypometabolis ...[more]