Dataset Information

First catheter-based high-density endocardial 3D electroanatomical mapping of the right atrium in standing horses.

ABSTRACT:

Background

Three-dimensional electroanatomical mapping is of potential interest in equine cardiology to identify arrhythmia mechanisms, characterise electroanatomical substrates and guide ablation strategies.

Objectives

To describe three-dimensional electroanatomical mapping in standing horses.

Study design

Research methodology, proof of concept study.

Methods

Four Standardbred horses (2 geldings, 2 mares, median age 4.5 [4-9] years, mean bodyweight 485 [440-550] kg) were sedated and placed in stocks. Via the jugular vein, a high-density multipolar grid catheter (Advisor^™ HD Grid Mapping Catheter with EnSite VelocityTM, Abbott Medical) was used for endocardial mapping of the right atrium. The P-wave on the surface ECG was used as a timing reference for simultaneous local activation time- and bipolar voltage-mapping. For a positional reference a 10-pole catheter (Abbott Medical) was placed in the caudal vena cava.

Results

Endocardial right atrial mapping guided by the three-dimensional mapping system and local electrograms was successfully performed in all four horses. A median of 32719 [25499-65078] points, covering the entire right atrium, were collected. Three-dimensional electroanatomical mapping provided detailed information about activation patterns and electrogram-characteristics of the sinoatrial node, intervenous tubercle and cavotricuspid isthmus. Additionally, transvenous biopsy forceps connected to the mapping system were visualised on screen to guide biopsy collection.

Main limitations

The feasibility of electroanatomical mapping for the left atrium and in larger breeds requires further study.

Conclusions

High-density three-dimensional electroanatomical mapping of the right atrium is feasible in the standing horse.

SUBMITTER: Hesselkilde E

PROVIDER: S-EPMC7818172 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

First catheter-based high-density endocardial 3D electroanatomical mapping of the right atrium in standing horses.

Hesselkilde Eva E Linz Dominik D Saljic Arnela A Carstensen Helena H Kutieleh Rayed R Jespersen Thomas T Sanders Prashanthan P Buhl Rikke R

Equine veterinary journal 20200514 1

<h4>Background</h4>Three-dimensional electroanatomical mapping is of potential interest in equine cardiology to identify arrhythmia mechanisms, characterise electroanatomical substrates and guide ablation strategies.<h4>Objectives</h4>To describe three-dimensional electroanatomical mapping in standing horses.<h4>Study design</h4>Research methodology, proof of concept study.<h4>Methods</h4>Four Standardbred horses (2 geldings, 2 mares, median age 4.5 [4-9] years, mean bodyweight 485 [440-550] kg) ...[more]

PMID: 32285961

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Project description:BACKGROUND:Spatial resolution in cardiac activation maps based on voltage measurement is limited by far-field interference. Precise characterization of electrical sources would resolve this limitation; however, practical charge-based cardiac mapping has not been achieved. METHODS:A prototype algorithm, developed from first principles of electrostatic field theory, derives charge density (CD) as a spatial representation of the true sources of the cardiac field. The algorithm processes multiple, simultaneous, noncontact voltage measurements within the cardiac chamber to inversely derive the global distribution of CD sources across the endocardial surface. RESULTS:Comparison of CD to an established computer-simulated model of atrial conduction demonstrated feasibility in terms of spatial, temporal, and morphologic metrics. Inverse reconstruction matched simulation with median spatial errors of 1.73 mm and 2.41 mm for CD and voltage, respectively. Median temporal error was less than 0.96 ms and morphologic correlation was greater than 0.90 for both CD and voltage. Activation patterns observed in human atrial flutter reproduced those established through contact maps, with a 4-fold improvement in resolution noted for CD over voltage. Global activation maps (charge density-based) are reported in atrial fibrillation with confirmed reduction of far-field interference. Arrhythmia cycle-length slowing and termination achieved through ablation of critical points demonstrated in the maps indicates both mechanistic and pathophysiological relevance. CONCLUSION:Global maps of cardiac activation based on CD enable classification of conduction patterns and localized nonpulmonary vein therapeutic targets in atrial fibrillation. The measurement capabilities of the approach have roles spanning deep phenotyping to therapeutic application. TRIAL REGISTRATION:ClinicalTrials.gov NCT01875614. FUNDING:The National Institute for Health Research (NIHR) Translational Research Program at Royal Papworth Hospital and Acutus Medical.

Dataset Information

First catheter-based high-density endocardial 3D electroanatomical mapping of the right atrium in standing horses.

Background

Objectives

Study design

Methods

Results

Main limitations

Conclusions

Publications

First catheter-based high-density endocardial 3D electroanatomical mapping of the right atrium in standing horses.

Similar Datasets

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