Dataset Information

Rapid Recovery Is Feasible for Aseptic Revision Total Knee Arthroplasty at an Academic Medical Center.

ABSTRACT:

Background

We reviewed the results of a primary total knee arthroplasty (TKA) rapid recovery care pathway applied to patients undergoing aseptic revision TKA. We sought to determine (1) the frequency of postoperative day (POD) 1 discharge, (2) the risk of adverse events, and (3) patient characteristics or surgical factors associated with failure to discharge on POD 1.

Methods

The source population was revision TKAs performed by a single surgeon at an academic medical center from 2016 to 2019 (n = 94). A primary TKA rapid recovery care pathway was applied to all patients who underwent aseptic revision TKA involving both femoral and tibial components (n = 33). Patients discharged on POD 1 (n = 21) were compared with those discharged on POD 2 or later (n = 12).

Results

The study cohort was 70% women, 12% under-represented minorities, and 70% government insured. Patients each had an average of 5 comorbidities. The average length of stay was 1.7 days, with 64% of patients discharged on POD 1. Ninety-seven percent of patients were discharged home. Although 18% of patients presented to the emergency room (ER) after discharge, there was no increased risk of readmission (P = .9336) or return to the ER (P = .9849) with POD 1 discharge. The LOS was unaffected by patient characteristics or complexity of surgical reconstruction.

Conclusions

Using a rapid recovery care pathway for aseptic revision TKA is feasible at an academic medical center. All patients may be considered for this pathway. Close postoperative monitoring is essential to minimizing ER visits, which are not uncommon.

SUBMITTER: Pontasch J

PROVIDER: S-EPMC7818602 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Rapid Recovery Is Feasible for Aseptic Revision Total Knee Arthroplasty at an Academic Medical Center.

Pontasch Josef J Sahlani Mario M Nandi Sumon S

Arthroplasty today 20210115

<h4>Background</h4>We reviewed the results of a primary total knee arthroplasty (TKA) rapid recovery care pathway applied to patients undergoing aseptic revision TKA. We sought to determine (1) the frequency of postoperative day (POD) 1 discharge, (2) the risk of adverse events, and (3) patient characteristics or surgical factors associated with failure to discharge on POD 1.<h4>Methods</h4>The source population was revision TKAs performed by a single surgeon at an academic medical center from 2 ...[more]

PMID: 33521206

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Project description:BACKGROUND:The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immune response. Several cytokines have shown increased systemic concentrations (in serum/plasma) in response to implants and infection, but tissue-level cytokines have not been investigated as thoroughly. METHODS:This exploratory study investigated tissue-level cytokines in a cohort of patients (N?=?17) in response to total knee arthroplasty and total knee revision to better understand the immune response to implants and localized infection (e.g., prosthetic joint infection). The overall goal of this study was to provide insight into the localized cytokine response of tissues and identify tissue-level markers specific to inflammation caused by implants vs. inflammation caused by infection. Tissues were collected across several anatomical locations and assayed with a panel of 20 human inflammatory cytokines to understand spatial differences in cytokine levels. RESULTS:In this study, six cytokines were elevated in implanted joints, as compared to native joints: IL-10, IL-12p70, IL-13, IL-17A, IL-4, and TNF-? (p?<?0.05). Seven cytokines showed infection-dependent increases in localized tissues: IL-1?, IL-1?, IL-6, IL-8, MCP-1, MIP-1?, and MIP-1? (p?<?0.05). CONCLUSIONS:This study demonstrated that differences exist in tissue-level cytokines in response to presence of implant, and some cytokines were specifically elevated for infection; these responses may be informative of overall tissue health. These results highlight the utility of investigating localized cytokine concentrations to offer novel insights for total knee arthroplasty and total knee revision procedures, as well as their complications. Ultimately, this information could provide additional, quantitative measurements of tissue to aid clinical decision making and patient treatment options.

Project description:There is debate in the literature whether rotating hinge knee (RHK) or constrained condylar knee (CCK) prostheses lead to better clinical outcomes and survival rates in patients undergoing revision total knee arthroplasty (RTKA). The purpose of this meta-analysis is to compare the survivorship and clinical outcomes of RHK and CCK prostheses. In this meta-analysis, we reviewed studies that evaluated pain and function scores, range of motion (ROM), complications, and survival rates in patients treated with RHK or CCK with short-term (<5 years) or midterm (5-10 years) follow-up. The survivorship was considered as the time to additional surgical intervention such as removal or revision of the components. A total of 12 studies (one randomized study and 11 non-randomized studies) met the inclusion criteria and were analyzed in detail. The proportion of the knees in which short-term (<5 years) survival rates (RHK, 83/95; CCK, 111/148; odds ratio [OR] 0.52; 95% CI, 0.24-1.11; P = 0.09) and midterm (5-10 years) survival rates (RHK, 104/128; CCK, 196/234; OR 1.05; 95% CI, 0.56-1.97; P = 0.88) were evaluated did not differ significantly between RHK and CCK prostheses. In addition, there were no significant differences in ROM (95% CI: -0.40 to 9.93; P = 0.07) and complication rates (95% CI: 0.66 to 2.49; P = 0.46). In contrast, CCK groups reported significantly better pain score (95% CI: 0.50 to 2.73; P = 0.005) and function score (95% CI: 0.01 to 2.00; P = 0.05) than RHK groups. This meta-analysis revealed that 87.4% of RHK and 75.0% of CCK prostheses survive at short-term (<5 years), while 81.3% of RHK and 83.8% of CCK prostheses survive at midterm (5-10 years). The differences in standardized mean pain and function scores we detected were likely to be imperceptible to patients and almost certainly below the minimum clinically important level, despite a significant difference in both groups. Based on the findings of the current meta-analysis, RHK prostheses continue to be an option in complex RTKA with reasonable midterm survivorship.

Dataset Information

Rapid Recovery Is Feasible for Aseptic Revision Total Knee Arthroplasty at an Academic Medical Center.

Background

Methods

Results

Conclusions

Publications

Rapid Recovery Is Feasible for Aseptic Revision Total Knee Arthroplasty at an Academic Medical Center.

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