Ontology highlight
ABSTRACT:
SUBMITTER: Shaw JB
PROVIDER: S-EPMC7819135 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Shaw Jared B JB Liu Weijing W Vasil Ev Yury V YV Bracken Carter C CC Malhan Neha N Guthals Adrian A Beckman Joseph S JS Voinov Valery G VG
Analytical chemistry 20191212 1
One challenge associated with the discovery and development of monoclonal antibody (mAb) therapeutics is the determination of heavy chain and light chain pairing. Advances in MS instrumentation and MS/MS methods have greatly enhanced capabilities for the analysis of large intact proteins yielding much more detailed and accurate proteoform characterization. Consequently, direct interrogation of intact antibodies or F(ab')2 and Fab fragments has the potential to significantly streamline therapeuti ...[more]