Anti-inflammatory effect of different curcumin preparations on adjuvant-induced arthritis in rats.

ABSTRACT:

Background

Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. The main drawback of curcumin is its poor solubility in water, which leads to low intestinal absorption and minimal bioavailability. In this study, we aimed to compare the anti-arthritic in vivo effect of different curcumin preparations - basic curcumin extract, micellar curcumin, curcumin mixture with piperine, and microencapsulated curcumin.

Methods

Arthritis was induced in Wistar rats by complete Freund's adjuvant, and the severity of arthritis was evaluated daily using the arthritis score system. Curcumin preparations were given to animals per os daily for 20 consecutive days, startin

SUBMITTER: Rinkunaite I 

PROVIDER: S-EPMC7819195 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature