Mitophagy protects ? cells from inflammatory damage in diabetes.
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ABSTRACT:
SUBMITTER: Sidarala V
PROVIDER: S-EPMC7819751 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Mitophagy protects β cells from inflammatory damage in diabetes.
Sidarala Vaibhav V Pearson Gemma L GL Parekh Vishal S VS Thompson Benjamin B Christen Lisa L Gingerich Morgan A MA Zhu Jie J Stromer Tracy T Ren Jianhua J Reck Emma C EC Chai Biaoxin B Corbett John A JA Mandrup-Poulsen Thomas T Satin Leslie S LS Soleimanpour Scott A SA
JCI insight 20201217 24
Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D, respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in impaired bioenergetics and initiation of proapoptotic machinery. Hence, the identification of protective responses to inflammation could lead to new therapeutic targets. Here, we report that mitophagy serves as a protective response to inflammatory stress in both human and rodent β cells. Utilizing in vivo mitophagy re ...[more]
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