Ontology highlight
ABSTRACT:
SUBMITTER: Pedrosa L
PROVIDER: S-EPMC7820010 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Pedrosa Lucía L Fernández-Miranda Ismael I Pérez-Callejo David D Quero Cristina C Rodríguez Marta M Martín-Acosta Paloma P Gómez Sagrario S González-Rincón Julia J Santos Adrián A Tarin Carlos C García Juan F JF García-Arroyo Francisco R FR Rueda Antonio A Camacho Francisca I FI García-Cosío Mónica M Heredero Ana A Llanos Marta M Mollejo Manuela M Piris-Villaespesa Miguel M Gómez-Codina José J Yanguas-Casás Natalia N Sánchez Antonio A Piris Miguel A MA Provencio Mariano M Sánchez-Beato Margarita M
Scientific reports 20210121 1
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease whose prognosis is associated with clinical features, cell-of-origin and genetic aberrations. Recent integrative, multi-omic analyses had led to identifying overlapping genetic DLBCL subtypes. We used targeted massive sequencing to analyze 84 diagnostic samples from a multicenter cohort of patients with DLBCL treated with rituximab-containing therapies and a median follow-up of 6 years. The most frequently mutated genes were IGLL5 ...[more]