Unknown

Dataset Information

0

A cross-species assessment of behavioral flexibility in compulsive disorders.


ABSTRACT: Lack of behavioral flexibility has been proposed as one underlying cause of compulsions, defined as repetitive behaviors performed through rigid rituals. However, experimental evidence has proven inconsistent across human and animal models of compulsive-like behavior. In the present study, applying a similarly-designed reversal learning task in two different species, which share a common symptom of compulsivity (human OCD patients and Sapap3 KO mice), we found no consistent link between compulsive behaviors and lack of behavioral flexibility. However, we showed that a distinct subgroup of compulsive individuals of both species exhibit a behavioral flexibility deficit in reversal learning. This deficit was not due to perseverative, rigid behaviors as commonly hypothesized, but rather due to an increase in response lability. These cross-species results highlight the necessity to consider the heterogeneity of cognitive deficits in compulsive disorders and call for reconsidering the role of behavioral flexibility in the aetiology of compulsive behaviors.

SUBMITTER: Benzina N 

PROVIDER: S-EPMC7820021 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

A cross-species assessment of behavioral flexibility in compulsive disorders.

Benzina Nabil N   N'Diaye Karim K   Pelissolo Antoine A   Mallet Luc L   Burguière Eric E  

Communications biology 20210121 1


Lack of behavioral flexibility has been proposed as one underlying cause of compulsions, defined as repetitive behaviors performed through rigid rituals. However, experimental evidence has proven inconsistent across human and animal models of compulsive-like behavior. In the present study, applying a similarly-designed reversal learning task in two different species, which share a common symptom of compulsivity (human OCD patients and Sapap3 KO mice), we found no consistent link between compulsi  ...[more]

Similar Datasets

| S-EPMC6377126 | biostudies-literature
| S-EPMC6487954 | biostudies-literature
| S-EPMC5472118 | biostudies-literature
2014-04-30 | GSE47972 | GEO
2014-04-30 | E-GEOD-47972 | biostudies-arrayexpress
| S-EPMC8551223 | biostudies-literature
2014-04-30 | GSE47970 | GEO
2014-04-30 | GSE47695 | GEO
2014-04-30 | E-GEOD-47695 | biostudies-arrayexpress
2014-04-30 | E-GEOD-47970 | biostudies-arrayexpress