Ontology highlight
ABSTRACT:
SUBMITTER: Benzina N
PROVIDER: S-EPMC7820021 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Benzina Nabil N N'Diaye Karim K Pelissolo Antoine A Mallet Luc L Burguière Eric E
Communications biology 20210121 1
Lack of behavioral flexibility has been proposed as one underlying cause of compulsions, defined as repetitive behaviors performed through rigid rituals. However, experimental evidence has proven inconsistent across human and animal models of compulsive-like behavior. In the present study, applying a similarly-designed reversal learning task in two different species, which share a common symptom of compulsivity (human OCD patients and Sapap3 KO mice), we found no consistent link between compulsi ...[more]