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Far field superlensing inside biological media through a nanorod lens using spatiotemporal information.

ABSTRACT: Far field superlensing of light has generated great attention in optical focusing and imaging applications. The capability of metamaterials to convert evanescent waves to propagative waves has led to numerous proposals in this regard. The common drawback of these approaches is their poor performance inside strongly scattering media like biological samples. Here, we use a metamaterial structure made out of aluminum nanorods in conjunction with time-reversal technique to exploit all temporal and spatial degrees of freedom for superlensing. Using broadband optics, we numerically show that this structure can perform focusing inside biological tissues with a resolution of ?/10. Moreover, for the imaging scheme we propose the entropy criterion for the image reconstruction step to reduce the number of required optical transducers. We propose an imaging scenario to reconstruct the spreading pattern of a diffusive material inside a tissue. In this way super-resolution images are obtained.

SUBMITTER: Hajiahmadi MJ

PROVIDER: S-EPMC7820502 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Far field superlensing inside biological media through a nanorod lens using spatiotemporal information.

Hajiahmadi Mohamad J MJ Faraji-Dana Reza R Skrivervik Anja K AK

Scientific reports 20210121 1

Far field superlensing of light has generated great attention in optical focusing and imaging applications. The capability of metamaterials to convert evanescent waves to propagative waves has led to numerous proposals in this regard. The common drawback of these approaches is their poor performance inside strongly scattering media like biological samples. Here, we use a metamaterial structure made out of aluminum nanorods in conjunction with time-reversal technique to exploit all temporal and s ...[more]

PMID: 33479283

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Project description:Biological excitable media, such as cardiac or neural cells and tissue, exhibit memory in which a change in the present excitation may affect the behaviors in the next excitation. For example, a change in calcium (Ca2+) concentration in a cell in the present excitation may affect the Ca2+ dynamics in the next excitation via bi-directional coupling between voltage and Ca2+, forming a delayed feedback loop. Since the Ca2+ dynamics inside the excitable cells are spatiotemporal while the membrane voltage is a global signal, the feedback loop is then a delayed global feedback (DGF) loop. In this study, we investigate the roles of DGF in the genesis and stability of spatiotemporal excitation patterns in periodically-paced excitable media using mathematical models with different levels of complexity: a model composed of coupled FitzHugh-Nagumo units, a 3-dimensional physiologically-detailed ventricular myocyte model, and a coupled map lattice model. We investigate the dynamics of excitation patterns that are temporal period-2 (P2) and spatially concordant or discordant, such as subcellular concordant or discordant Ca2+alternans in cardiac myocytes or spatially concordant or discordant Ca2+ and repolarization alternans in cardiac tissue. Our modeling approach allows both computer simulations and rigorous analytical treatments, which lead to the following results and conclusions. When DGF is absent, concordant and discordant P2 patterns occur depending on initial conditions with the discordant P2 patterns being spatially random. When the DGF is negative, only concordant P2 patterns exist. When the DGF is positive, both concordant and discordant P2 patterns can occur. The discordant P2 patterns are still spatially random, but they satisfy that the global signal exhibits a temporal period-1 behavior. The theoretical analyses of the coupled map lattice model reveal the underlying instabilities and bifurcations for the genesis, selection, and stability of spatiotemporal excitation patterns.

Dataset Information

Far field superlensing inside biological media through a nanorod lens using spatiotemporal information.

Publications

Far field superlensing inside biological media through a nanorod lens using spatiotemporal information.

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