Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate.
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ABSTRACT:
SUBMITTER: Ota T
PROVIDER: S-EPMC7820547 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate.
Ota Tomoki T Senoo Akinobu A Shirakawa Masumi M Nonaka Hiroshi H Saito Yutaro Y Ito Sho S Ueno Go G Nagatoishi Satoru S Tsumoto Kouhei K Sando Shinsuke S
iScience 20210106 2
Bile acids are metabolites of cholesterol that facilitate lipid digestion and absorption in the small bowel. Bile acids work as agonists of receptors to regulate their own metabolism. Bile acids also regulate other biological systems such as sugar metabolism, intestinal multidrug resistance, and adaptive immunity. However, numerous physiological roles of bile acids remain undetermined. In this study, we solved the crystal structure of human serine hydroxymethyltransferase (hSHMT) in complex with ...[more]
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