Ontology highlight
ABSTRACT:
SUBMITTER: Dieterich IA
PROVIDER: S-EPMC7820588 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Dieterich Inca A IA Cui Yusi Y Braun Megan M MM Lawton Alexis J AJ Robinson Nicklaus H NH Peotter Jennifer L JL Yu Qing Q Casler Jason C JC Glick Benjamin S BS Audhya Anjon A Denu John M JM Li Lingjun L Puglielli Luigi L
Scientific reports 20210121 1
Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransferases, ATase1 and ATase2, which acetylate nascent polypeptides within the ER lumen. Dysfunctional AT-1, as caused by gene mutation or duplication events, results in severe disease phenotypes. Here, we used two models of AT-1 dysregulation to investigate dynamic ...[more]