Effect of corticosteroid therapy in the early phase of acute respiratory distress syndrome: a propensity-matched cohort study.

ABSTRACT:

Background/aims

It is unclear whether corticosteroid use in patients with acute respiratory distress syndrome (ARDS) improves survival. This study aimed to investigate whether the administration of corticosteroids to patients in the early phase of moderate to severe ARDS is associated with improved outcomes.

Methods

We analyzed the data of patients who received corticosteroids within 7 days of the onset of ARDS between June 2006 and December 2015 at a single tertiary teaching hospital. A total of 565 patients admitted with moderate to severe ARDS were eligible. The outcomes of patients treated with methylprednisolone 40 to 180 mg/day or equivalent (n = 404) were compared to those who did not receive steroids (n = 161). The primary and secondary outcomes were 28- and 90-day m

SUBMITTER: Baek MS 

PROVIDER: S-EPMC7820645 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature