Dataset Information

The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients.

ABSTRACT: HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+) and that HLA-B^*27:04 was the dominant HLA-B27 subtype (N = 224). In all participants, HLA^*27:04 homozygous were only detected in two patients. In the HLA-B27(+) group, HLA-B40 was observed in 51 cases and one control (p < 0.05, OR = 7.87, 95% CI 1.05-59.0); of these, the most genotype was HLA-B^*27:04/B^*40:01(N = 38). Two hundred thirty-nine patients' clinical information was recorded. Cases with HLA-B27/B46 had more peripheral joint involvement (OR = 3.95, 95% CI 1.77-8.79) in HLA-B27(+) AS. HLA-B^*15:02 may be a significant risk element to peripheral joint involvement (p < 0.05) in HLA-B27(-) patients. Therefore, we believe HLA-B^*40:01, HLA-B^*46:01, and HLA-B^*15:02 can be the test indicators for AS diagnostic value.

SUBMITTER: Wu X

PROVIDER: S-EPMC7820707 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients.

Wu Xinyu X Wu Jialing J Li Xiaomin X Wei Qiujing Q Lv Qing Q Zhang Pingping P Zheng Xuqi X Chen Zena Z Cao Shuangyan S Tu Liudan L Gu Jieruo J

Frontiers in medicine 20210108

HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+) and that HLA-B*27:04 was the dominant HLA-B27 subtype (N = 224). In all participants, HLA*27:04 homozygous were only detected in two patients. In the HLA-B27(+) group, HLA-B40 was observed in 51 cases and one contr ...[more]

PMID: 33490092

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Project description:ObjectivesTo study clinical characteristics, mortality, and secondary prevention, after a first incident acute myocardial infarction (AMI) in patients with ankylosing spondylitis (AS) compared with the general population.MethodsIn total, 292 subjects with AS and a first AMI between Jan 2006 and Dec 2014 were identified using the Swedish national patient register. Each subject was matched with up to 5 general population comparators per AS-patient (n = 1276). Follow-up started at the date of admission for AMI and extended until death or 365 days of follow-up. Cox regression was used to assess mortality in two time intervals: days 0-30 and days 31-365. For a subgroup with available data, clinical presentation at admission, course, treatment for AMI, and secondary prevention were compared.ResultsDuring the 365-day follow-up, 56/292 (19%) AS patients and 184/1276 (14%) comparators died. There were no difference in mortality due to cardiovascular-related causes, although the overall mortality day 31-365 was increased among patients with AS compared with comparators (HR [95% CI] = 2.0 [1.3;3.0]). At admission, AS patients had a higher prevalence of cardiovascular comorbidities compared with comparators. At discharge, patients with AS were less often prescribed lipid-lowering drugs and non-aspirin antiplatelet therapy.ConclusionsPatients with AS tend to have a higher comorbidity burden at admission for first AMI. The mortality after a first AMI due to cardiovascular-related causes does not seem to be elevated, despite an increased overall mortality during days 31-365 among patients with AS compared with the general population. Key Points • The all-cause mortality after a first AMI was higher in patients with AS. • Mortality after a first AMI due to CVD-related causes does not seem to be elevated for patients with AS. • In patients with AS suffering a first AMI, more attention should be given to other comorbidities causing an excess in mortality.

Dataset Information

The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients.

Publications

The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients.

Similar Datasets

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