Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Garcia P
PROVIDER: S-EPMC7821110 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
López-García Patricia P de Araujo Aline D AD Bergues-Pupo Ana E AE Tunn Isabell I Fairlie David P DP Blank Kerstin G KG
Angewandte Chemie (International ed. in English) 20201029 1
Coiled coils (CCs) are powerful supramolecular building blocks for biomimetic materials, increasingly used for their mechanical properties. Here, we introduce helix-inducing macrocyclic constraints, so-called staples, to tune thermodynamic and mechanical stability of CCs. We show that thermodynamic stabilization of CCs against helix uncoiling primarily depends on the number of staples, whereas staple positioning controls CC mechanical stability. Inserting a covalent lactam staple at one key forc ...[more]