Ontology highlight
ABSTRACT:
SUBMITTER: Seliger J
PROVIDER: S-EPMC7821270 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20201027 1
A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are ...[more]