Ontology highlight
ABSTRACT:
SUBMITTER: Lagisetty KH
PROVIDER: S-EPMC7821593 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lagisetty Kiran H KH McEwen Dyke P DP Nancarrow Derek J DJ Schiebel Johnathon G JG Ferrer-Torres Daysha D Ray Dipankar D Frankel Timothy L TL Lin Jules J Chang Andrew C AC Kresty Laura A LA Beer David G DG
JCI insight 20210111 1
Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), a chronic inflammatory state that can progress through a series of transformative dysplastic states before tumor development. While molecular and genetic changes of EAC tumors have been studied, immune microenvironment changes during Barrett's progression to EAC remain poorly understood. In this study, we identify potential immunologic changes that can occur during BE-to-EAC progression. RNA sequencing (RNA-Seq) analysis on ...[more]