Ontology highlight
ABSTRACT:
SUBMITTER: Barber-Axthelm IM
PROVIDER: S-EPMC7821595 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Barber-Axthelm Isaac M IM Barber-Axthelm Valerie V Sze Kai Yin KY Zhen Anjie A Suryawanshi Gajendra W GW Chen Irvin Sy IS Zack Jerome A JA Kitchen Scott G SG Kiem Hans-Peter HP Peterson Christopher W CW
JCI insight 20210111 1
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with CCR5- donor cells is the only treatment known to cure HIV-1 in patients with underlying malignancy. This is likely due to a donor cell-mediated graft-versus-host effect targeting HIV reservoirs. Allo-HSCT would not be an acceptable therapy for most people living with HIV due to the transplant-related side effects. Chimeric antigen receptor (CAR) immunotherapies specifically traffic to malignant lymphoid tissues (lymphomas) and, ...[more]