Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts.
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ABSTRACT: Background
We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts.Results
Following a standard-dose training period, excellence in endurance performance was less frequent among subjects with haplogroups J or K than among subjects with non-JK haplogroups (p =?0.041), and this finding was more apparent among the best-performing subjects (p ConclusionsThese results suggest that mtDNA haplogroups are one of the genetic determinants explaining individual variability in the adaptive response to endurance training, and mtDNA haplogroups J and K are markers of low-responders in exercise training.
SUBMITTER: Kiiskila J
PROVIDER: S-EPMC7821635 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts.
Kiiskilä Jukka J Jokelainen Jari J Kytövuori Laura L Mikkola Ilona I Härkönen Pirjo P Keinänen-Kiukaanniemi Sirkka S Majamaa Kari K
BMC genomics 20210122 1
<h4>Background</h4>We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts.<h4>Results</h4>Following a standard-dose training period, excellence in endurance performance was ...[more]
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