Physical activity modulates mononuclear phagocytes in mammary tissue and inhibits tumor growth in mice.

ABSTRACT: The risk for breast cancer is significantly reduced in persons who engage in greater amounts of physical activity, and greater physical activity before or after diagnosis associates with reduced disease-specific mortality. Previous mechanistic studies indicate that components of innate immunity can mediate an inhibitory effect of physical activity on several types of tumor. However, in breast cancer specifically, the myeloid compartment of innate immunity is thought to exhibit high propensity for an immunosuppressive role that obstructs anti-tumor immunity. Thus, we tested the notion that greater physical activity alters mononuclear phagocytes in mammary tissue when inhibiting nascent tumor in a murine model of breast cancer. To model greater physical activity, we placed an angled running

SUBMITTER: Lamkin DM 

PROVIDER: S-EPMC7821756 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature