Ontology highlight
ABSTRACT:
SUBMITTER: Weiss D
PROVIDER: S-EPMC7821897 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Science advances 20201204 49
Arterial tortuosity manifests in many conditions, including hypertension, genetic mutations predisposing to thoracic aortopathy, and vascular aging. Despite evidence that tortuosity disrupts efficient blood flow and that it may be an important clinical biomarker, underlying mechanisms remain poorly understood but are widely appreciated to be largely biomechanical. Many previous studies suggested that tortuosity may arise via an elastic structural buckling instability, but the novel experimental- ...[more]