Ontology highlight
ABSTRACT:
SUBMITTER: Toden S
PROVIDER: S-EPMC7821903 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Science advances 20201209 50
The lack of accessible noninvasive tools to examine the molecular alterations occurring in the brain limits our understanding of the causes and progression of Alzheimer's disease (AD), as well as the identification of effective therapeutic strategies. Here, we conducted a comprehensive profiling of circulating, cell-free messenger RNA (cf-mRNA) in plasma of 126 patients with AD and 116 healthy controls of similar age. We identified 2591 dysregulated genes in the cf-mRNA of patients with AD, whic ...[more]